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FLASH GENE
Symbol DNAJA2 contributors: mct/npt - updated : 27-08-2019
HGNC name DnaJ (Hsp40) homolog, subfamily A, member 2
HGNC id 14884
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DJA domain
  • a CR domain
  • farnesylated C terminus
  • conjugated LipoP , Other
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae corepressors of histone gene transcription Hir1p,Hir2p
    ortholog to murine Dnaja2
    homolog to rattus Dj2
    homolog to Drosophila CG9828
    homolog to C.elegans dnj-19
    intraspecies homolog to DNJ3/CPR3
    Homologene
    FAMILY
  • Hsp40 family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text
  • colocolizing with Hsp70 (HSPA*) after heat shock
  • identified in the mammalian cytosol (Abdul 2002)
  • basic FUNCTION
  • acting as a positive cochaperone of Hsp70
  • critical role of DNAJA1 in spermiogenesis, suggesting that likely DNAJA1 and DNAJA2 are not functionally equivalent
  • factor in the protection against prion diseases (Beck 2006)
  • modulates G protein signaling and further suggest that chaperoning G proteins is an emerging theme of the J protein network (Rosales-Hernandez 2009)
  • key modulator of KCNH2 degradation (Walker 2010)
  • with DNAJA1, cause a decrease in the amount of KCNH2 complexed with Hsc70, indicating a preferential degradation of the complex (Walker 2010)
  • role for the DJA proteins in regulating degradation suggesting that they act at a critical point in secretory pathway quality control (Walker 2010)
  • although functions of DNAJA2 and DNAJA1 independent of HSPA8 are possible, it is generally thought that their main roles are as co-chaperones of HSPA8
  • DNAJA2 is an unexpected, but potent, inhibitor of MAPT aggregation
  • DNAJA2 and DNAJA1 were both important for CFTR folding, however overexpressing DNAJA2 but not DNAJA1 enhanced CFTR degradation at the endoplasmic reticulum by HSPA4/HSPA8 and the E3 ubiquitin ligase STUB1
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text
  • positive regulation of cell proliferation
  • G1 phase of mitotic cell cycle
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to HIRA
  • AIPL1
  • is an enhancer of G-protein-coupled signaling by the ADRB2
  • essential role of specific DJA domains of DNAJA1 and DNAJA2 in the folding mechanism of HSPA8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS