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FLASH GENE
Symbol CDKL3 contributors: mct/npt - updated : 20-12-2021
HGNC name cyclin-dependent kinase-like 3
HGNC id 15483
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • MAP kinase dual phosphorylation motif, Thr-Aspi-Tyr motif in kinase subdomain 8
  • a Thr-X-Tyr (TXY) motif in the activation loop domain
  • a nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to Drosophila RKIALRE
    homolog to C.elegans KKIALRE
    intraspecies homolog to NKIAMRE (CDKL3)
    Homologene
    FAMILY
  • proline-directed kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • restricting cell growth or maintaining differentiation
  • may have a role in regulating cell growth and/or diferentiation
  • may be involved in proliferation of cells surrounding the brain ventricle where neuronal progenitor cells are enriched during the late embryo stage, supporting the notion that CDKL3 inactivation contributes to non-syndromic mild mental retardation (MR)
  • plays an important role in the regulation of cell growth and/or differentiation
  • is a critical regulator that stimulates Osteosarcoma (OS) progression by enhancing AKT1 activation
  • CELLULAR PROCESS cell life, differentiation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • regulator of cell cycle progression
  • maintenance of normal hematopoiesis
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDKL3 is a promotor for glioma, probably through the regulation of RRM2 and activation of the JNK signalling pathway
  • cell & other
    REGULATION
    activated by by treatment of cells with phorbol 12-myristate 13-acetate
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    in mental retardation
    tumoral   deletion    
    in dysmyelopoiesis
    tumoral     --over  
    in esophageal squamous cell carcinoma ESCC) with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for Osteosarcoma (OS) prognosis (
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    potential therapeutic target to treat AKT1 hyper-activated Osteosarcoma (OS)
    cancerdigestiveoesophagus
    may be as a new therapeutic target in ESCC
    cancerbrainglioma/neuroblstoma
    CDKL3 as a promising therapeutic target of glioma
    ANIMAL & CELL MODELS