SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microfilament
|
| intracellular,nucleus
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text
| filamentous pattern through the cytoplasm |
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full-length BIRC7 shows diffuse cytoplasmic localization, truncated form is found in a peri-nuclear distribution with marked localization to the Golgi apparatus |
basic FUNCTION
| involved in the regulation of apoptosis |
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important determinant for the apoptotic resistance of non-small cell lung cancer cells |
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may exert anti-apoptotic action by activating JNK1 signaling pathway and inhibiting caspase-3 activation |
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may contribute to drug resistance in neuroblastoma, and may be essential for survival of some cancer cells |
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has a role in thrombopoiesis by regulating the apoptotic and antiapoptotic balance in megakaryocyte endoreplication and platelet production |
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BIRC7,CASP3, BIRC5 are closely related to the occurrence and development of prostatic cancer |