Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BIRC6 contributors: mct/npt - updated : 28-04-2015
HGNC name baculoviral IAP repeat-containing 6 (apollon)
HGNC id 13516
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal baculovirus IAP repeat (BIR domain)
  • ubiquitin-conjugating enzyme (UBC) domain at the carboxy terminus
  • HOMOLOGY
    interspecies homolog to murine Bruce
    Homologene
    FAMILY
  • baculovirus IAP related family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text filamentous pattern through cytoplasm
    basic FUNCTION
  • playing a role in tumorigenesis (brain cancer) and drug resistance of the SNB-78 cell linee at least
  • multifunctional protein, which processes ubiquitin-conjugating activity, as a major regulator of abscission
  • coordinates multiple steps required for abscission and ubiquitylation may be a crucial trigger
  • antagonizes both the precursor and mature forms of Smac and caspase-9
  • having has an essential function in preventing DIABLO-induced apoptosis
  • is a target for glucocorticoid hormones (GHs) in the neural progenitor cells (NPCs), and controls cell division of NPCs and possibly of other stem cells
  • BIRC6 and USP8 are two hitherto uncharacterized critical DNA damage response (DDR) regulators
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to, ubiquitinates and facilitates proteasomal degradation of SMAC and caspase-9, which both contain IAP-binding motifs
  • may have a potential oncogenic role in neuroblastoma by inactivating cytoplasmic DIABLO
  • is potentially a novel regulator of mitotic CCCNA2 degradation independent of spindle assembly checkpoint (SAC)
  • expression of BIRC6 is upregulated by MTRNR2L1, and BIRC6 could be an effector of MTRNR2L1 in a context-dependent manner
  • acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8) and MCPH1 in a complex to coordinate USP8-catalyzed deubiquitination of MCPH1
  • regulates DNA double-strand break response by promoting USP8 deubiquitination of MCPH1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in castration-resistant prostate cancer (CRPC)
    tumoral     --over  
    associated with unfavorable clinical features and negatively impacts relapse-free survival in childhood acute myeloid leukemia (AML)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    BIRC6-based dual IAP-targeting ASOs represent potential novel therapeutic agents against advanced prostate cancer
    cancerbrainglioma/neuroblstoma
    BIRC6 inhibition may therefore provide a means for therapeutic intervention in neuroblastoma
    ANIMAL & CELL MODELS
  • Birc6-mutant mice exhibit repair defects and genomic instability