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FLASH GENE
Symbol FAM126A contributors: mct - updated : 12-11-2014
HGNC name family with sequence similarity 126, member A
HGNC id 24587
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Dretnnb1a
Homologene
FAMILY
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • tumor suppressor in colorectal cancer
  • may have a role in the beta-catenin/Lef signaling pathway
  • playing an essential role in myelinisation in both the central and peripheral nervous system
  • is likely involved in neuron-to-glia signalling to initiate or maintain myelination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    beta-catenin Tcf/Lef signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by beta-catenin
    ASSOCIATED DISORDERS
    corresponding disease(s) HCC
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS