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FLASH GENE
Symbol PSMF1 contributors: mct - updated : 28-06-2014
HGNC name proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
HGNC id 9571
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • proline rich protein particulary within its C-terminal half where one fourth of amino-acids are proline
  • secondary structure
  • FBXO7 FP domain adopts an alpha/beta-fold similar to that of the PSMF1 FP domain
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to chimpanzee LOC458030
    ortholog to murine Psmf1
    Homologene
    FAMILY proteasome inhibitor PI31 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • control of proteasome function including that in ubiquitin-dependent pathway of protein degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FP (FBXO7/PSMF1) domains found in the F-box protein FBXO7 and the proteasome inhibitor PSMF1 mediate the homodimerization and heterodimerization of FBXO7 and PSMF1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FBXO7 interacts with proteins that are not substrates of the ubiquitin proteasome system, such as CDK6 and PSMF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS