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FLASH GENE
Symbol ADNP contributors: mct - updated : 16-10-2015
HGNC name activity-dependent neuroprotector
HGNC id 15766
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine zinc fingers,
  • a proline-rich region,
  • a nuclear bipartite localization signal (NLS) and
  • a helix-turn-helix (homeo box) domain,including a neuroprotective peptide
  • HOMOLOGY
    interspecies homolog to murine Adnp
    intraspecies homolog to ADNP2
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • potential neuroprotective protein
  • may be involved in the stimulatory effect of VIP on certain tumor cells
  • is essential for brain formation, proper brain development and neuronal plasticity
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text cell survival,perhaps through modulation of p53
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VIP regulated brain ADNP expression in a regionally specific manner and both maternal and offspring VIP genotype may influence ADNP expression in the brain
  • imbalance in ADNP/ADNP2 expression in the brain may impact disease progression in schizophrenia
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HVDAS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    affects social interactions, a major hallmark of schizophrenia
    constitutional     --over  
    associated with the initial stages of the disease, possibly reflecting a compensatory effect
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Adnp haploinsufficiency in mice, results in age-related neuronal death, cognitive and social dysfunction, exhibited reduced hippocampal Becn1 and increased Bcl2 expression