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FLASH GENE
Symbol PFN2 contributors: mct - updated : 19-06-2013
HGNC name profilin 2
HGNC id 8882
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
binding to prolin rich motifs
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • involved in SMN mutations
  • actin binding proteins essential for regulating cytoskeletal dynamics
  • required for actin polymerization in the synapse, possibly through a pathway that involves the WAVE-complex
  • neuron specific, it provides an excellent target to regulate actin polymerization in the synapse and thereby modulate neurotransmitter homeostasis
  • key regulator of the actin microfilament system and in neuronal tissues
  • functional role for both profilins (PFN1, PFN2) in neuronal nuclei
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral , nervous system
    text profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SMN
  • binds to the neuronal protein palladin, including a synthetic palladin peptide
  • G-actin binding protein,preventing its polymerization to F-actin
  • SMN1 is directly interacting with profilin2a (PFN2 binds to a stretch of proline residues in SMN, which is heavily impaired by a novel SMN2 missense mutation)
  • directly interacts with ROCK1, a key player in actin regulation and neuronal differentiation
  • directly and specifically binds to the C-terminal domain of GRIK2 through a diproline motif
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS