basic FUNCTION
| involved in SMN mutations |
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actin binding proteins essential for regulating cytoskeletal dynamics |
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required for actin polymerization in the synapse, possibly through a pathway that involves the WAVE-complex |
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neuron specific, it provides an excellent target to regulate actin polymerization in the synapse and thereby modulate neurotransmitter homeostasis |
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key regulator of the actin microfilament system and in neuronal tissues |
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functional role for both profilins (PFN1, PFN2) in neuronal nuclei |