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FLASH GENE
Symbol DYRK4 contributors: mct - updated : 19-10-2011
HGNC name dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
HGNC id 3095
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative bipartite NLS within the extended N-terminal region
  • protein kinase domain
  • HOMOLOGY
    interspecies homolog to Drosophila minibrain
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • MNB/DYRK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • preferential cytoplasmic localization
  • basic FUNCTION
  • putatively involved in cell growth and development and in neuronal differentiation
  • testis-specific kinase with a very restricted expression to stage VIII postmeiotic spermatids, but dispensable for male fertility
  • autophosphorylated on tyrosine residues and the phosphorylation of the second tyrosine in the YXY motif is necessary for its kinase activity
  • can phosphorylate target sequences not recognized by DYRK1A or DYRK2
  • DYRK1A, DYRK2, and DYRK4 phosphorylate distinct although overlapping sets of the 720 different peptides in the phosphosite array
  • DYRK1A, DYRK3, DYRK4 implicated in the regulation of cytoskeletal organization and process outgrowth in neurons
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DCX is likely one relevant DYRK1A, DYRK3, DYRK4 target
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Dyrk4-deficient mice are fertile