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FLASH GENE
Symbol CPSF2 contributors: npt/mct - updated : 19/11/2008
HGNC name cleavage and polyadenylation specific factor 2, 100kDa
HGNC id 2325
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
Homologene
FAMILY
  • metallo-beta-lactamase superfamily
  • RNA-metabolizing metallo-beta-lactamase-like family
  • CPSF2/YSH1 subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • essential for maturation process
  • 3'processing of mRNAs precursors and subsequent polyadenylation
  • CPSF3 and CPSF2 act together in the process of maturation of eukaryotic pre-messenger RNAs, similar to other members of the MBL family, RNases Z and J, which function as homodimers
  • CELLULAR PROCESS nucleotide, transcription, maturation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text polyadenyaltion
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with CPSF1,3,4,poly (A) ribonuclease (PARN) and CSTF3 (cleavage stimulation factor 3)
  • INTERACTION
    DNA
    RNA binding to the AAUAA motif of the pre mRNA, upstream the cleavage site
    small molecule other, binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS