basic FUNCTION
| component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation |
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CPSF4 and its homologues are likely the actual nucleases that cleave pre-mRNA in the process of polyadenylation |
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plays a key role in mRNA polyadenylation and mRNA 3' ends maturation |
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plays a critical role in regulating lung cancer cell proliferation and survival |
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CPSF4 and WDR33 directly contact AAUAAA |
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key protein involved in pre-mRNA processing |
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CPSF1 functions as an essential scaffold and preorganizes CPSF4 and WDR33 for high-affinity binding to AAUAAA |
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selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF4/RNA binding |
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crucial tumorigenic factor in lung cancer development |
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both CPSF4 and WDR33 are required for high-affinity binding of the AAUAAA polyadenylation signal (PAS) RNA, while these two proteins alone and their binary complexes with CPSF1 have much lower affinity for the RNA |