motifs/domains
| first PHD domain (PHD1 AAs 306-360) is located at the N-terminus and is important for both histone demethylase activity and histone-tail recognition of KDM5B , and may help maintain KDM5B at target genes to mediate the demethylation activities of KDM5B |
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first and third, but not the second, PHD fingers of KDM5B possess histone binding activities |
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three DNA-binding PHD/LAP zinc finger motifs |
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a specific DNA-binding motif found in Drosophila protein dri and other conserved motifs |
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a PLU domain |
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two bipartic nuclear localization signals (NLS) |
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a JmjC domain containing the catalytic pocket for demethylation |
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a Bright/Arid domain and zinc-finger-like domain are for protein/DNA and protein/protein interactions, a potential DNA-binding domain of KDM5B |
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atypical insertion of a DNA-binding ARID domain and a histone-binding PHD domain into the Jumonji domain, which separates the catalytic domain into two fragments (JmjN and JmjC) |
basic FUNCTION
| testis-cancer antigen regulating genes expression in breast cancer |
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acting as a transcriptional co-repressor of two unrelated developmental transcription factors(BF-1 and PAX9)interacting with members of the groucho co-repressor family, and may be having a role in groucho-mediated transcriptional repression |
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playing a role in in meiotic transcription, which may be restricted to certain meiotic stages and may be mediated by the ability of this protein to associate with the chromatin |
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demethylase capable of removing three methyl groups from histone H3 lysine 4 and up-regulated in prostate cancer |
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regulates the AR transcriptional function |
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regulates cell cycle control genes in cancer and is expressed in the early epiblast |
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specifically demethylates lysine 4 of histone H3 (meH3K4), thereby repressing gene transcription |
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playing a role in the choice between proliferation and differentiation during development |
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crucial role in H3K4me3 demethylation |
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iron- and - alpha ketoglutarate-dependent dioxygenase |
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KLF10 and JARID1B may cooperate to suppress tumorigenesis by enhancing TGFB signaling |
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KLF10 and JARID1B cooperate in repressing SMAD7 transcription and thereby antagonize skin cancer development |
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potentially activates self-renewal-associated gene expression by repressing cryptic initiation and maintaining an H3K4me3 gradient important for productive transcriptional elongation |
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functional contribution of its overexpression with concomitant epigenetic dysregulation in cancer progression |
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play a critical role in the development of breast cancer |
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essential role for KDM5B-mediated transcriptional control during embryonic stem cell differentiation |
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KDM5A and KDM5B demethylases are tumor-suppressor network controlling cellular senescence |
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regulate the expression of genes involved in cell cycle progression |
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demethylates H3K4, is important for ES cell differentiation and presents a barrier to the reprogramming process |
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KDM5B and KDM1A, another H3K4 demethylase, co-regulate H3K4 methylation at active promoters but they retain distinct roles in demethylating gene body regions and bivalent genes |
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positively regulates mammary ductal development through both extrinsic and cell-autonomous mechanisms |
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removes methyl residues from methylated lysine 4 on histone H3 lysine 4 (H3K4) |
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pivotal role in stimulating metastatic behaviors of HCC cells |
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is a key component of a potent epigenetic switch that controls mesenchymal cell fate into myogenic and osteogenic lineages |
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enzymatic activity of the KDM5 family required to be the linked JmjN-JmjC domain coupled with the immediate C-terminal helical zinc-binding domain, providing structural characterization of the linked JmjN-JmjC domain for the KDM5 family |
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