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FLASH GENE
Symbol PFDN5 contributors: npt/ - updated : 21-09-2004
HGNC name prefoldin subunit 5
HGNC id 8869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal putative leucine zipper motif
  • mono polymer heteromer , hexamer
    HOMOLOGY
    interspecies ortholog to murine Pfdn5
    Homologene
    FAMILY
  • prefoldin subunit alpha family
  • CATEGORY chaperone/stress , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • regulation of transcription, DNA-dependent
  • assisting in the correct folding of other proteins
  • transfering target proteins to cytosolic chaperonin
  • promoting folding in an environment in which there are many competing pathways for nonnative proteins
  • repressing the transcriptional activity of c-myc and activation from promoters containing E-boxes
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    text transcription co-repressor
    PATHWAY
    metabolism
    signaling
    a component
  • heterohexamer of two PFD-alpha type and four PFD-beta type subunits
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding specifically to cytosolic chaperonin (C-CPN), nascent polypeptide chain, c-myc and p73
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS