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FLASH GENE
Symbol PFDN4 contributors: npt/ - updated : 25-06-2008
HGNC name prefoldin subunit 4
HGNC id 8868
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • helix-loop-helix (HLH) motif
    • mono polymer heteromer , hexamer
    HOMOLOGY
    Homologene
    FAMILY
  • prefoldin beta subunit family
    • CATEGORY chaperone/stress , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • assisting in the correct folding of other proteins
  • transfering target proteins to cytosolic chaperonin (C-CPN)
  • promoting folding in an environment in which there are many competing pathways for nonnative proteins
  • playing a role during G1-S phase transition phase of the cell cycle
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins
    • CELLULAR PROCESS nucleotide, transcription
    protein, editing
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterohexamer of two PFD-alpha type and four PFD-beta type subunits
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding specifically to cytosolic chaperonin (C-CPN)binding to nascent polypeptide chain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS