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FLASH GENE
Symbol ZNF274 contributors: mct - updated : 18-01-2014
HGNC name zinc finger protein 274
HGNC id 13068
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • at N terminus, two Krüppel associated box (KRAB)A domains, a KRAB domain which can bind the TRIM28 protein in a 1:3 ratio (KRAB:TRIM28) with KRAB at the center of the complex
  • a leucine rich region
  • five zinc finger motifs C2H2 type
  • one KRABA domain is missing in ZNF274b
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • transcriptional repressor playing a role in the nucleolus
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ZNF274 binding sites co-localize with SETDB1, TRIM28, and H3K9me3 at the 3prime ends of zinc finger genes
  • stimulation of the MAS1 protein should result in increased nitric oxide, potentially nitrating the ZNF274/TRIM28 complex,
  • resulting in dissociation of TRIM28 and activation of the transcription of MAS1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS