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FLASH GENE
Symbol CSNK1G1 contributors: shn - updated : 13-10-2012
HGNC name casein kinase 1, gamma 1
HGNC id 2454
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a kinase domain
  • a C terminal region divided into two structural domains
  • a specific proximal highly basic
  • a most terminal motif common to the L isoform and Rcsk1
  • conjugated PhosphoP
    mono polymer monomer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to Csnk1g1, Rattus norvegicus
    ortholog to Csnk1g1, Mus musculus
    ortholog to csnk1g1, danio rerio
    ortholog to CSNK1G1, Pan troglodytes
    Homologene
    FAMILY Ser/Thr protein kinase family, casein kinase I subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in growth and morphogenesis of eukaryotic cells
  • participating in Wnt signaling by phosphorylating LRP6 and mediating the recruitment of axin
  • is a novel component of checkpoint responses that controls the interaction of a key checkpoint effector kinase with its cognate mediator protein
  • phosphorylates the CHEK1-activating domain of Claspin
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    protein
    PHYSIOLOGICAL PROCESS
    text
  • growth and morphogenesis of eukaryotic cells
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    Other regulated by autophosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • depletion of CSNK1G1 from human cells by siRNA results in dramatically diminished phosphorylation of Claspin and cells display impaired activation of Chk1 and resultant checkpoint defects