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FLASH GENE
Symbol GULP1 contributors: mct/npt/shn - updated : 14-06-2017
HGNC name GULP, engulfment adaptor PTB domain containing 1
HGNC id 18649
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phosphotyrosine-binding (PTB) domain
  • a potential Src-homology domain 3 (SH3) binding sites
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Gulp1, Mus musculus
    ortholog to Gulp1, Rattus norvegicus
    ortholog to GULP1, Pan troglodytes
    ortholog to gulp1, Danio rerio
    Homologene
    FAMILY
  • ced-6 family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating the phagocytosis of apoptotic cells
  • adaptor protein required for efficient engulfment of apoptotic cells by phagocytes
  • playing an important role in stabilin-2-mediated phagocytosis
  • required for actin reorganization around the apoptotic cell corpse
  • GULP1 is a modifier of cellular ARF6-GTP through regulation of ACAP1
  • functions as an adaptor protein for stabilin-1-mediated phagocytosis
  • is a novel APP/(APP C-terminal domain-interacting protein that influences APP processing and Abeta production
  • because GULP1 expression positively regulates TGFB1 signaling leading to growth inhibition, this may represent an attractive target to achieve TGFB1 responsiveness in ovarian cells
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CED-1 and CD91/low density lipoprotein receptor-related protein,LRP
  • role for GULP1 as a positive regulator of ARF6
  • SCARB1 binds to engulfment adapter protein (GULP1) using the C-terminal intracellular domain, and PS-recognizing SCARB1 activates associated GULP1
  • is able to specifically interact with the NPxF/Y motif of STAB1 cytoplasmic region
  • GULP1-APP interaction is mediated by the NPTY motif of APP and the GULP1 PTB (phosphotyrosine-binding) domain
  • is an adapter to LRP1 and mediates TGFB1 signaling in signaling-competent early endosomes
  • GULP1 mediates LRP1 transactivation
  • PEAR1 associates with GULP1, the mammalian homologue of Ced-6, an adaptor protein required for phagocytosis mediated by the nematode engulfment receptor Ced-1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS