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FLASH GENE
Symbol CLEC5A contributors: mct - updated : 11-10-2011
HGNC name C-type lectin domain family 5, member A
HGNC id 2054
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-type lectin domain
  • lectin-like fold similar to the natural-killer T-cell C-type lectin domains and associates with a 12-kDa DNAX-activating protein (DAP12)4 on myeloid cells
    • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Clecsf5
    Homologene
    FAMILY
  • C type lectin superfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type II transmembrane protein
    basic FUNCTION
  • involved in activation of myeloid cells in a calcium-dependent manner
  • ABC-transporter involved in peptide export from the matrix space, having minor effects on nuclear gene expression
  • important pattern recognition receptor in the context of dengue virus infection
  • acting as a signaling receptor for proinflammatory cytokine release
  • CLEC5A associates with both TYROBP and HCST in osteoclasts and bone marrow-derived macrophages, where HCST association depends almost entirely on TYROBP
  • key regulator of synovial injury and bone erosion during autoimmune joint inflammation
  • cell surface receptor strongly associated with the activation and differentiation of myeloid cells
  • associates with its adaptor protein TYROBP to activate a signaling cascade resulting in activation of downstream kinases in inflammatory responses
  • critical macrophage receptor for dengue virus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling signal transduction
    CLECSF5/DAP12 pathway
    a component homodimeric at the cell surface and binds to dengue virus serotypes 1-4
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with TYROBP
  • interacts with dnax-activation protein 12
    • cell & other
  • interacts with the dengue virion
    • REGULATION
    Other down-regulated when monocytes differentiate into dendritic cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    mRNA expression was significantly lower in primary acute myeloid leukemia (AML) patient samples than in macrophages and granulocytes from healthy donors
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunearticular
    may be a therapeutic target for treatment of immune-mediated skeletal disorders
    ANIMAL & CELL MODELS