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FLASH GENE
Symbol SIGLEC9 contributors: mct/npt - updated : 19-01-2013
HGNC name sialic acid binding Ig-like lectin 9
HGNC id 10878
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • three extracellular immunoglobulin-like domains
  • a N terminal V-set and two proximal C2-Set domains
  • a transmembrane region
  • a cytoplasmic tail containing two putative tyrosine-based signaling motifs, the proximal fitting the immunoreceptor tyrosine base inhibitory motif (ITIM), critical for the inhibitory signaling mediated
  • light potential N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to SIGLEC5,SIGLEC7,SIGLEC8,CD33
    Homologene
    FAMILY
  • sialoadhesin family
  • immunoglobulin superfamily
  • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating sialic acid-dependent binding to red cells and glycoconjugates
  • "CD33"-related siglecs expressed on natural killer (NK) cells and subsets of peripheral T cells
  • capable of negative regulation of TCR signaling and ligand binding is required for optimal activity
  • initiating apoptotic (ROS- and caspase-dependent) and nonapoptotic (ROS-dependent) death pathways in neutrophils
  • enhances the production of the anti-inflammatory cytokine IL10 in macrophages
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text tumoral cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recognize sialic acid-containing glycans of glycoproteins and glycolipids as ligands
  • induce cell death in adult polymorphonuclear neutrophils in association with PTPN6
  • physically interact with PTPN6, and age-specific interactions between SIGLEC9 and PTPN6 may influence the altered inflammatory responsiveness and longevity of neonatal polymorphonuclear neutrophils
  • MUC16-SIGLEC9 binding likely mediates inhibition of anti-tumor immune responses
  • binding between SIGLEC9 and AOC3 (is a novel leukocyte ligand for AOC3and can be used in PET imaging of inflammation and cancer)
  • MUC16 intreracting with SIGLEC9
  • SIGLEC9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS