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FLASH GENE
Symbol CABP2 contributors: mct - updated : 17-11-2012
HGNC name calcium binding protein 2
HGNC id 1385
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • only three functional Ca2+-binding EF-hand domains (EF hands 1, 3, and 4) because EF hand 2 contains a 3 AA deletion that would inhibit Ca2+ binding
  • three thioredoxin boxes (Cys-Gly-His-Cys)
  • consensus sequence for N-myristiolation with multiple spliced variants
  • HOMOLOGY
    interspecies homolog to Cabp2
    intraspecies homolog to calmodulin
    Homologene
    FAMILY
  • calcium binding protein subfamily
  • protein disulphide-isomerase (PDI) family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • may be involved in the folding of nascent proteins
  • both CABP2 and CABP1 may promote oxidative folding by different kinetic pathways
  • role in the mammalian auditory system
  • might be required for normal hearing through roles in other cell types besides inner hair cells
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of calcium mediated cellular signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • calcium ion binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB93
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS