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FLASH GENE
Symbol STOML2 contributors: mct/pgu - updated : 23-02-2013
HGNC name stomatin (EPB72)-like 2
HGNC id 14559
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lacking the N terminal hydrophobic domain of stomatin
  • bipartite region containing beta sheet and alpha helix structure, a domain similar to a 172 AA region of the HSA stomatin polypeptide and mostly alpha helical C terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
  • stomatin superfamily
  • band 7/mec-2 family
  • CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    text
  • associated with the inner mitochondrial membrane and faces the intermembrane space
  • strongly associated with the mitochondrial inner membrane
  • basic FUNCTION
  • maybe involved in regulating ion channel conductance or the organization of sphyngolipid and cholesterol rich microdomains (rafts)
  • imported into mitochondria in a membrane potential-dependent manner and that the import is accompanied by proteolytic processing
  • mitochondrial intermembrane space/inner membrane-localized protein that forms a large hetero-oligomeric complex with MFN2
  • plays a role in regulating the stability of mitochondrial proteins including prohibitins and subunits of respiratory chain complexes
  • is required for stress-induced mitochondrial hyperfusion
  • with STOML1 may form part of a docking complex, capturing secretory lysosomes at the immunological synapse
  • late endosomal protein, contributing to secretory lysosome exocytosis from cytotoxic T lymphocytes
  • important player in T cell activation by ensuring sustained TCR signaling, which is required for full effector T cell differentiation
  • its function is potentially to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text ion channel conductance
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MFN2 (may interact with the intermembrane space loop of MFN2)
  • interacts with prohibitins
  • interacts with prohibitin-1 and -2 and binds to the mitochondrial membrane phospholipid cardiolipin
  • cell & other
  • the peripheral erythrocyte cytoskeleton and probably other integral membrane proteins
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum anti-TPM3, anti-TMOD3, anti-STOML2 could be new markers for the early diagnosis of endometriosis
  • Therapy target
    ANIMAL & CELL MODELS