SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,cytoskeleton
|
text
| associated with the inner mitochondrial membrane and faces the intermembrane space |
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strongly associated with the mitochondrial inner membrane |
basic FUNCTION
| maybe involved in regulating ion channel conductance or the organization of sphyngolipid and cholesterol rich microdomains (rafts) |
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imported into mitochondria in a membrane potential-dependent manner and that the import is accompanied by proteolytic processing |
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mitochondrial intermembrane space/inner membrane-localized protein that forms a large hetero-oligomeric complex with MFN2 |
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plays a role in regulating the stability of mitochondrial proteins including prohibitins and subunits of respiratory chain complexes |
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is required for stress-induced mitochondrial hyperfusion |
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with STOML1 may form part of a docking complex, capturing secretory lysosomes at the immunological synapse |
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late endosomal protein, contributing to secretory lysosome exocytosis from cytotoxic T lymphocytes |
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important player in T cell activation by ensuring sustained TCR signaling, which is required for full effector T cell differentiation |
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its function is potentially to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled |