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FLASH GENE
Symbol PGM3 contributors: mct - updated : 26-08-2014
HGNC name phosphoglucomutase 3
HGNC id 8907
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four domains
  • active site is made up of one loop from each of the four: the serine loop in domain 1, the metal-binding loop in domain 2, the sugar-binding loop in domain 3, and the phosphate-binding loop in domain 4
  • HOMOLOGY
    Homologene
    FAMILY
  • phosphohexose mutases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • bifunctional enzyme
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycoproteins
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2R
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    is a potential molecular therapeutic target for prostate cancer
    ANIMAL & CELL MODELS
  • Pgm3-/- mice die in early embryogenesis and show a dramatic reduction in UDP-GlcNAc (pMID: 24931394)
  • mice lacking Pgm3 die prior to implantation, animals with less severe reductions in enzyme activity are sterile, exhibit changes in pancreatic architecture, and are anemic, leukopenic, and thrombocytopenic