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FLASH GENE
Symbol ARFIP2 contributors: mct - updated : 27-10-2011
HGNC name ADP-ribosylation factor interacting protein 2
HGNC id 17160
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BAR (Bin/Amphiphysin/Rvs) domain, which participates in membrane deformation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • associate with trans-Golgi membranes (recruited onto trans-Golgi membranes by interacting with ARL1, and capable of inducing membrane deformation via its BAR domain)
  • basic FUNCTION
  • involved in regulating huntingtin protein aggregation, possibly by impairing proteasome function
  • had a neuroprotective effect on striatal neurons when phosphorylated by AKT1, and inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment
  • may have the ability to deform membranes or amplify and stabilize the membrane curvature
  • potentially involved in distinct transport processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAC1
  • interacts with all Arf proteins examined and an Arf-like protein, ARL1
  • binding partners of the ARF small GTPases
  • interact with ARL1 through its BAR domain-containing region and compete for ARL1 binding with GOLGA1 and GOLGA4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS