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FLASH GENE
Symbol CRYAB contributors: mct/shn - updated : 02-10-2012
HGNC name crystallin, alpha B
HGNC id 2389
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • N-terminal domain involved in multiple interactions that enable the formation of various oligomers and binding to denatured proteins, thereby enabling chaperone-like activities, and the hydrophobic region (AAs 41–58) of the N-terminal domain is involved in the recognition of denatured protein
  • a C-ter with the alpha cristallin domain responsible for chaperone function, undergoing many post-translational modifications, noteworthy phosphorylation and cleavage
    • mono polymer heteromer , aggregate , complex
    HOMOLOGY
    interspecies ortholog to Cryab, Rattus norvegicus
    ortholog to Cryab, Mus musculus
    ortholog to CRYAB, Pan troglodytes
    ortholog to cryaba, Danio rerio
    intraspecies homolog to CRYAA
    Homologene
    FAMILY
  • alpha crystallin superfamily
  • small heat shock protein (sHSP or HSP20) subfamily
    • CATEGORY chaperone/stress , motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • contributing to the refractive index and transparency of lens
  • preventing the aggregation of the crystallins and proteins
  • having chaperone-like activity
  • involvend in maintenance of cytoskeletal network in muscle
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    photoreception
    a component
  • complexing with CRYAA (ratio AA3/AB1) (30-40 subunits, 600-800 kDa)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRYAA and HSP28 with PSMA7
  • proteasomal subunit C8/alpha7 (
  • citrate synthase (
  • betaB2- or gammaC-crystallins (
  • TITIN, TTN (
  • Bax and Bcl-X(S) (
  • Alzheimer's disease beta-amyloid peptide (
  • histone deacetylase inhibitor, HDACI (
  • LBH
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DRM , CPP2 , CMD1II , MMFIH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
          --over  
    in Alexander disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Cryab-/- mice showed worse experimental autoimmune encephalomyelitis at the acute and progressive phases, with higher Th1 and Th17 cytokine secretion from T cells and macrophages, and more intense central nervous system inflammation (
  • AxD mouse models that loss of Cryab results in increased mortality (