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FLASH GENE
Symbol FAM20B contributors: mct - updated : 25-01-2019
HGNC name glycosaminoglycan xylosylkinase
HGNC id 23017
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor
HOMOLOGY
interspecies ortholog to murine C530043G21Rik
Homologene
FAMILY FAM20 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • potential functions in regulating differentiation and function of hematopoietic and other tissues
  • is a kinase that phosphorylates the xylose residue in the linkage region
  • regulates likely the number of glycosaminoglycan chains by phosphorylating the xylose residue in the glycosaminoglycan-protein linkage region of proteoglycans
  • XYLT1, and FAM20B function in cartilage matrix production and ultimately regulate the timing of skeletal development
  • FAM20B phosphorylates the initiating xylose residue in the proteoglycan tetrasaccharide linkage region, and this event functions as a molecular switch to regulate subsequent glycosaminoglycan assembly
  • FAM20B-catalyzed proteoglycans regulate postnatal endochondral ossification partially through the mediation of WNT signaling.
  • FAM20B is essential for the formation of glycosaminoglycan (GAG) chains
  • phosphorylates the initial xylose on the side chain of a serine residue in the protein
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • proteoglycans formed through the catalysis of FAM20B are essential for the morphogenesis and mineralization of the craniofacial complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS