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FLASH GENE
Symbol UBN1 contributors: shn - updated : 02-02-2013
HGNC name ubinuclein 1
HGNC id 12506
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domains of the UBN1 and TJP1 proteins triggered a functional interaction inside the cell
  • five acidic regions
  • a serine-rich domain
  • three main basic nuclear localization signal-like regions
  • a HRD domain (Hpc2p-related domain)
  • a NHRD domain being an essential region for HIRA interaction and chromatin organization by the HUCA complex
  • HOMOLOGY
    interspecies ortholog to Hpc2p, yeast
    ortholog to Ubn1, Mus musculus
    ortholog to zgc:171747, Danio rerio
    ortholog to Ubn1, Rattus norvegicus
    Homologene
    FAMILY member of the bZIP family
    CATEGORY storage , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nucleus,nucleolus
    text
  • punctate nuclear staining in cultured keratinocytes
  • UBN1 is localized throughout the nucleoplasm in proliferating primary human fibroblasts
  • basic FUNCTION
  • may be playing a role in maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus
  • UBN1 is indispensable for formation of senescence-associated heterochromatin foci (SAHF)
  • UBN1 is an indispensable component of the HIRA/ASF1a SAHF assembly pathway
  • UBN1 is a regulator of senescence
  • scaffold protein influencing protein subcellular localization and is involved in several processes such as cell-cell contact signalling or modulation of gene activity
  • CELLULAR PROCESS cell life, senescence
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of the quaternary HIRA/UBN1/CABIN1/ASF1A (HUCA) complex, assembled from recombinant proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cellular and viral epstein-Barr BLZ1 early gene EB1 transcription factors
  • DKC1, FBL
  • UBN1 binds to the Epstein-Barr virus EB1 protein
  • UBN1 binds to the WD repeats of chromatin regulator HIRA
  • interaction between N-terminal domains of UBN1 and TJP1 proteins inside the cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS