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FLASH GENE
Symbol BCL6B contributors: mct - updated : 25-01-2014
HGNC name B-cell CLL/lymphoma 6, member B (zinc finger protein)
HGNC id 1002
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • BTB/POZ domain
  • five repeats of the Krüppel-like zinc finger motif at the N and C terminus
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Bcl6b
    intraspecies homolog to BCL6
    Homologene
    FAMILY BTB/POZ family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • repressor, having protein binding activity
  • regulating differentiation in stages or lineages different from those regulated by BCL6
  • required for the enhanced magnitude of the secondary response of memory CD8(+) T cells
  • BCL6 and BCL6B regulate hematopoietic progenitor cells (HPC) homeostasis by an indirect pathway involving CD8 T cell
  • mediates KDR and Notch cross-signaling in angiogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • FGF2 depends on MAP2K1 signaling to drive spermatogonial stem cell (SSC) self-renewal via upregulation of the ETV5 and BCL6B genes
  • PRKD2, mediated BCL6B gene expression by VEGFA stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS