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FLASH GENE
Symbol HEY1 contributors: mct - updated : 23-10-2015
HGNC name hairy/enhancer-of-split related with YRPW motif 1
HGNC id 4880
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) N terminal domain
  • an orange domain
  • a YRPW motif
  • a protein protein interaction motif near the C terminus
  • HOMOLOGY
    interspecies homolog to murine Hey1
    Homologene
    FAMILY
  • basic helix-loop-helix family of trasncription factor HERP
  • Hairy/Enhancer-of-split-related with YRPW-like motif (HEY) family of proteins
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • implicated in cell fate decision and boundary formation
  • involved in dopamine-related polygenic disorders and behavioral traits
  • invoved in controlling Notch induced endocardial epithelial to mesenchymal transition, a process critical for valve and septum formation
  • with HEY2, are the downstream mediators of the prosensory function of Notch in early cochlear development
  • AR-selective corepressor that contains both HDAC-dependent and -independent repression domains
  • through its interplay with RUNX2, may play an important role in regulating BMP9-induced osteoblast lineage differentiation of pluripotent mesenchymal stem cells
  • inhibits myogenesis by associating with and repressing expression of key myogenic targets
  • HESR family (HEY1, HEY2, HEYL)is involved in dopamine transporter (SLC6A3) expression via the VNTR domain
  • HEY1 and HEY2 selectively repress androgen receptor (AR) signaling in mammalian cell lines
  • HEY1 and HEYL (which are known Notch target genes) are expressed simultaneously in skeletal muscle only in satellite cells
  • HEY1 and HEYL are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis
  • critical scaffolding function for HEY1, HEY2 that is required for forming an active retrotranslocation complex containing SYVN1, SEL1L, and DERL2
  • information provided by HES1/HEY1 downstream of NOTCH1 as well as myogenic regulatory factors (MRFs) activities are integrated at the level of the CDKN1C enhancer to regulate the decision between progenitor cell maintenance and muscle differentiation
  • critical role for HEY1 and HEY2 in prosensory cell maintenance and identifies Hedgehog signaling as a novel upstream regulator of their prosensory function in the mammalian cochlea
  • important role of HEY1 and HEY2 in endothelial cells during early vascular development
  • HEY1 augmented the metastasis of osteosarcoma via upregulation of MMP9 expression
  • CELLULAR PROCESS nucleotide, transcription
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with NOTCH1 (primary target gene of NOTCH1)
  • interacts with HEYL
  • may be a direct target of the GDF2-induced Smad signaling pathway
  • through its interplay with RUNX2, may play an important role in regulating GDF2-induced osteoblast lineage differentiation of mesenchymal stem cells
  • interaction with RUNX2 (RUNX2 act synergistically in BMP9-induced osteogenic differentiation, and RUNX2 expression significantly decreased in the absence of HEY1 suggesting that RUNX2 may function downstream of HEY1
  • recruited to the promoter regions of myogenin and MEF2C, two genes whose induction is critical for myogenesis
  • ADAM10-dependent regulation of DLL1 and DLL4 expression in association with changes in HES1 and HEY1 expression
  • MMP9 was a downstream effector of HEY1 that promotes the invasion of osteosarcoma cells
  • HEY1 mediated nuclear translocation of FBXO45 and its associated ubiquitin ligase complex may extend its spectrum to additional nuclear targets triggering their ubiquitination
  • cell & other
    REGULATION
    activated by NOTCH1
    MSX1 (strongly up-regulated the Delta-Notch pathway genes DLK1, NOTCH3, and HEY1)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    inactivation of HEY1 and HEYL, two primary target genes of Notch, causes severe heart malformations, including membranous ventricular septal defects and dysplastic atrioventricular and pulmonary valves
    tumoral     --over  
    in glioblastoma)
    tumoral       gain of function
    in human osteosarcoma
    tumoral fusion      
    HEY1-NCOA2 fusion in mesenchymal chondrosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker molecular marker to distinguish glioblastoma multiforme patients with a longer survival prognosis from those at high risk
    Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    inhibition of HEY1 may be a novel therapeutic strategy for preventing osteosarcoma metastasis
    cancerbrainglioma/neuroblstoma
    therapeutic target for glioblastoma patients
    ANIMAL & CELL MODELS