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FLASH GENE
Symbol GGA2 contributors: mct/npt - updated : 19-04-2015
HGNC name golgi associated, gamma adaptin ear containing, ARF binding protein 2
HGNC id 16064
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • VHS domain at N terminus
  • a typical ear domain at C terminus
  • GAT domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ADP-ribosylation factor binding protein family
  • GGA protein family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in vesicle transport through trans-Golgi (facilitation of the trafficking of proteins between trans-Golgi network and lysosome)
  • sorting MGP receptors and lysosome enzymes
  • implicated in the sorting of mannose 6-phosphate receptor (MPR) (Hida 2007)
  • recruited to the TGN independently of the other GGAs and required for the efficient sorting of lysosomal enzymes (Hida 2007)
  • monomeric clathrin adaptors that mediate cargo sorting and vesicle formation at the TGN (Del Castillo 2010)
  • conserved role for GGA1, GGA2, GGA3 proteins in regulating phosphatidylinositol 4-kinase function at the TGN
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    text heterotopic vesicle/suborganelle interactions associated with the Gogi complex
    PATHWAY
    metabolism
    signaling
    a component
  • complexing through the VHS domain with the cytoplasmic domains of sorting receptors such as the mannose phosphate receptor by recognizing the acidic cluster dileucine (ACLL) sequences
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting by its VHS domain with the cytoplasmic tail of sortilin SORT1
  • binding BACE
  • interaction between GGA1, GGA2, GGA3 and RABEP1 is likely to take place in a pathway between the trans-Golgi network and early endosomes
  • bind PI4P primarily through their GAT domain, in a region called C-GAT that also binds ubiquitin (Wang 2007)
  • associated with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors
  • interacting with CNST (Del Castillo 2010)
  • MON2 directly interacts with GGA1, GGA2, GGA3 through the VHS domain
  • PI4KB interacted preferentially with the VHS domain of GGA2 compared with VHS domains of GGA1 and GGA3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS