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FLASH GENE
Symbol SPARCL1 contributors: mct/npt - updated : 20-12-2016
HGNC name SPARC-like 1 (mast9, hevin)
HGNC id 11220
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • glycoprotein cystein-rich
  • a highly acidic domain-I,
  • a follistatin-like domain
  • and an extracellular calcium (EC) binding domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to SPARC
    Homologene
    FAMILY
  • secreted protein, acidic and rich in cysteine (SPARC) family matricellular protein
  • osteonectin family of proteins
  • CATEGORY adhesion , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocyte adhesion receptor for high endothelium
  • regulating the terminal phase of radial glia-guided migration in the cerebral cortex
  • having important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix (Sullivan 2006)
  • regulates dermal extracellular matrix and collagen fibril formation (Sullivan 2006)
  • having the capacity to modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly (Sullivan 2006)
  • having anti-invasive effects and reduced expression in metastasis of pancreatic cancer (Esposito 2007)
  • can influence the function of astroglial cells in the developing and mature central nervous system (CNS) (Weimer 2008)
  • may be a component of the 'matrix response' involved in remodeling events associated with neuronal degeneration following neural injury (Lively 2008)
  • does not appear to be critical to regulating intraocular pressure (IOP), is expressed in trabecular meshwork (TM) but, in contrast to SPARC, does not appear to be regulated by TGFB2
  • is required for the structural maturation of the retinocollicular synapses
  • SPARCL1 is a positive and SPARC is a negative regulator of synapse formation
  • possible role for this protein in the progression of the glioma
  • is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence
  • is a matricellular protein involved in tissue repair and remodeling via interaction with the surrounding extracellular matrix (ECM) proteins
  • plays a pivotal role in the corneal wound healing
  • SPARCL1-containing neurons function to relay and regulate motor and sensory signals in the human brainstem
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS cardiovascular
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in clear cell renal carcinoma with good outcome
    tumoral     --low  
    may be related to inactivation of its tumor suppressor functions and might play an important role in the development of gastric adenocarcinoma
    tumoral     --over  
    in primary colorectal adenocarcinomas and slightly expressed in their lymph node metastases
    Susceptibility to multiple sclerosis (minor role) (Scalabrini 2007)
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression of SPARCL1 protein might be a valuable biomarker for early diagnosis in colorectal cancers and further predicting patients' prognosis
  • Therapy target
    ANIMAL & CELL MODELS
  • Blbf-Sparcl1 transgenic mice show elevated Sparcl1 transcript and protein in an astroglial selective pattern throughout the CNS (Weimer 2008)
  • Hevin-null mice had fewer excitatory synapses
  • Hevin (-/-) mice develop early corneal haze characterized by severe chronic inflammation and stromal fibrosis that can be rescued with exogenous administration of rhHevin