basic FUNCTION
| lymphocyte adhesion receptor for high endothelium |
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regulating the terminal phase of radial glia-guided migration in the cerebral cortex |
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having important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix (Sullivan 2006) |
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regulates dermal extracellular matrix and collagen fibril formation (Sullivan 2006) |
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having the capacity to modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly (Sullivan 2006) |
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having anti-invasive effects and reduced expression in metastasis of pancreatic cancer (Esposito 2007) |
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can influence the function of astroglial cells in the developing and mature central nervous system (CNS) (Weimer 2008) |
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may be a component of the 'matrix response' involved in remodeling events associated with neuronal degeneration following neural injury (Lively 2008) |
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does not appear to be critical to regulating intraocular pressure (IOP), is expressed in trabecular meshwork (TM) but, in contrast to SPARC, does not appear to be regulated by TGFB2 |
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is required for the structural maturation of the retinocollicular synapses |
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SPARCL1 is a positive and SPARC is a negative regulator of synapse formation |
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possible role for this protein in the progression of the glioma |
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is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence |
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is a matricellular protein involved in tissue repair and remodeling via interaction with the surrounding extracellular matrix (ECM) proteins |
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plays a pivotal role in the corneal wound healing |
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SPARCL1-containing neurons function to relay and regulate motor and sensory signals in the human brainstem |