motifs/domains
| a globular N terminus domain |
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helical C terminal domain potentially forming a coiled-coil (critical for the subcellular targeting of DISC1) by interaction with other undefined proteins |
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three leucine zipper domains |
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two UVR-like domains, mediating potentially its self-association |
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two nuclear localization signal |
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region 446-533 AAs is the kendrin-binding region |
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C-terminal NDEL1 binding domain, narrowed down to a small portion of exon 13, corresponding to amino acids 802-835, indispensable for the interaction with kendrin and also required for the centrosomal targeting of DISC1 , which harbors also a dimerization domain and is considered necessary for neuronal migration complex assembly (PMID; |
basic FUNCTION
| involved in the regulation of microtubule dynamics |
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DISC1-kendrin interaction plays a key role in the microtubule dynamics ( |
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is a multifunctional protein whose truncation may contribute to schizophrenia susceptibility by disrupting intracellular transport, neurite architecture, and/or neuronal migration |
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essential for maintaining the motor complex at the centrosome |
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involved in cortical development through its interaction with other proteins |
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crucial role of NDEL1, together with DISC1 in cortical layer formation |
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sequestering PDE4B in resting cells and releasing it in an activated state in response to elevated cAMP |
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playing a role in neuronal outgrowth, possibly through reported interactions with the molecules NDEL1 and FEZ1 |
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key regulator that orchestrates the tempo of functional neuronal integration in the adult brain and acting as a susceptibility gene for major mental illness in neuronal development, including adult neurogenesis |
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acting as a linker between Kinesin-1 and DISC1-interacting molecules, such as NudE-like, PAFAH1B1, and YWHAE |
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required for NTF3-induced axon elongation and ERK activation at the distal part of axons by recruiting GRB2 to axonal tips |
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regulates the localization of NDEL1/PAFAH1B1/YWHAE complex into the axons as a cargo receptor for axon elongation |
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acting as an assembly scaffold for NDE1/NDEL1/LIS1/dynein complex modulated by cAMP levels via Protein Kinase A and PDE4 |
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highly expressed in neural progenitor cells and required for their proliferation involving regulation of the b-catenin/GSK3b pathway |
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stabilizes b-catenin by inhibiting GSK3b activity through a direct interaction |
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regulate neuronal progenitor proliferation by modulating GSK3B-catenin signalling |
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involved in neurite outgrowth, neuronal migration, integration of newborn neurons, and cAMP signaling |
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participates in the Wnt signaling pathway and in Wnt-mediated cell proliferation |
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essential for neural progenitor proliferation in embryonic brains and in the dentate gyrus of adult brains through its ability to fine-tune GSK3b activity |
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role in neuronal migration in the developing and adult hippocampus ( |
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having a role in glial function ( |
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regulates the recruitment of pericentriolar material 1 (PCM1) to the centrosome ( |
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critical for the stability of Mitofilin (IMMT) ( |
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plays essential roles for mitochondrial function in collaboration with a mitochondrial interacting partner, Mitofilin (IMMT)( |
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lays roles for intrinsic mitochondrial functions through regulation of the stability of Mitofilin, a mitochondrial interacting partner ( |
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dual role in corticogenesis and indicate that phosphorylation of DISC1 activates a key developmental switch ( |
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DISC1 functional activity is potentially downstream of NMDA receptor signaling |
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YWHAE and DISC1, two schizophrenia susceptibility factors have been implicated in the regulation of spine density |
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is likely necessary for the migration of the cortical interneurons generated in the medial ganglionic eminence (MGE) |
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FOXP2, DISC1 and the NRXN family in a molecular network that, when altered, confers risk for neurodevelopmental conditions in which various aspects of linguistic and cognitive function are disturbed, possibly via aberrant synaptic function |
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direct presynaptic function for the schizophrenia-associated gene, DISC1 |
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intracellular scaffolding molecule thought to act an important hub for protein interactions involved in signalling for neural cell differentiation and function |
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multifunctional scaffolding protein that regulates cyclic adenosine monophosphate (cAMP) signaling via interactions with PDE4 |
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DISC1 and CHL1 may engage in physical and functional interaction in neural development |