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FLASH GENE
Symbol GPRC5B contributors: mct - updated : 12-07-2016
HGNC name G protein-coupled receptor, family C, group 5, member B
HGNC id 13308
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) with a short extracellular N terminal domain
  • conjugated GlycoP
    isoforms Precursor a 27 aa signal peptide of 3.1 kda, a 376 mature peptide of 41.7 kda
    HOMOLOGY
    interspecies homolog to rattus Gprc5b (87.1 pc)
    homolog to murine Gprc5b (87.6 pc)
    intraspecies paralog to RAIG1,RAIG3
    Homologene
    FAMILY
  • type 3 G protein-coupled receptor family
  • group C family of G protein-coupled receptors (GPCRs)
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleolus
    text
  • cytoplasmic vesicle membrane
  • basic FUNCTION
  • acting as a metabotropic glutamate, GABA-B-like receptor
  • may be a major node in adipose signaling systems linking diet-induced obesity to type 2 diabetes
  • GPRC5B-mediated signalling is associated with the proper regulation of CTNNB1 signalling, a pathway crucial for progenitor fate decision
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/vision
  • visual perception
  • Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway
  • adaptor protein CD2AP-mediated internalization following cell surface delivery appears to contribute to the Golgi accumulation of GPRC5B, possibly in parallel with biosynthetic/secretory trafficking from the endoplasmic reticulum
  • cell & other
    REGULATION
    induced by all-trans retinoic acid
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    pharmacological targeting of GPRC5B might provide a novel means therapy for the treatment and prevention of type 2 diabetes
    ANIMAL & CELL MODELS
    Gprc5b-deficient mice were protected from diet-induced obesity and insulin resistance because of reduced inflammation in their white adipose tissue