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FLASH GENE
Symbol PCOLCE2 contributors: KTN/npt - updated : 30-01-2009
HGNC name procollagen C-endopeptidase enhancer 2
HGNC id 8739
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal signal sequence of 23 aa
  • two CUB domains at the N terminus
  • an NTR domain at the C terminus
  • a putative myristoylation site
  • several potential phosphorylation sites
  • a putative glycosylation site
  • an RGD site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Pcolce2 (87.4 pc)
    intraspecies homolog to PCOLCE
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION
  • enhancing cleavage of type I procollagen C-propeptide by BMP1 (Steiglitz 2002)
  • activating BMP1
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the COOH-terminal propeptide of type I procollagen (Steiglitz 2002)
  • interacting with heparin with high affinity and type II collagen (Steiglitz 2002)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for GLC1C (Xu 2000)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS