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FLASH GENE
Symbol MKNK2 contributors: mct - updated : 06-05-2015
HGNC name MAP kinase interacting serine/threonine kinase 2
HGNC id 7111
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a complete serine/threonine kinase domain including a DLG/Asp-Leu-Gly preceded by a DFD (Asp-Phe-Asp) motifs
  • a potential nuclear localization signal (NLS)
  • several potential MAP kinase phosphorylation sites
  • a C terminal ERK docking site homolog
  • conjugated PhosphoP
    mono polymer homomer , monomer
    HOMOLOGY
    interspecies homolog to rattus Mknk2 (94.3 pc)
    homolog to murine Mknk2 (95.4 pc)
    intraspecies paralog to MKNK1, other dependent MAP-kinase dependent kinase
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • CATEGORY enzyme , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may play a role in the response to environmental stress and cytokines
  • regulating transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap
  • MKNK1, MKNK2 are protein-serine/threonine kinases that are activated by ERK or MAPK14 and phosphorylate EIF4E, which is involved in cap-dependent translation initiation
  • oncogenic role for MKNK1/MKNK2 in tumor development
  • key role for the MKNK1, MKNK2/EIF4E pathway in the regulatory effects of IFNG on normal hematopoiesis
  • plays a unique role, not shared by its closest paralog MKNK1, in limiting protein translation through its negative effect on eIF4G1 Serıı&
  • 8304;&
    8312; phosphorylation and RPS6KB1 activation
  • MKNK1, MKNK2, has a minimal role in T cell development and activation but may regulate non-T cell lineages to control Th1 and Th17 differentiation
  • MKNK1, MKNK2 play important roles in controlling signals involved in mRNA translation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • cell surface receptor linked signal transduction
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • binding to Mg2+
  • binding to Zn2+ (one ion per subunit)
  • ATP
  • protein
  • estrogen receptor beta (ERB)
  • interacting with the C-terminal regions of EIF4G1 and EIF4G2
  • also binding to dephosphorylated ERK1 and ERK2
  • interacting with ESR2 (variant 1)
  • HNRNPA1 recruitment to stress granules involves MKNK1/MKNK2-dependent phosphorylation of mRNA-bound HNRNPA1
  • MKNK1/MKNK2-EIF4G1 interaction is important for EIF4E phosphorylation
  • previously unrecognized role for BANK1 in CpG-induced responses by splenic B cells on MAPK14 signaling and control of translation initiation of IL6 via MKNK1/MKNK2 and EIF4E
  • MKNK1, MKNK2 increased the binding of EIF4E to the cytoplasmic FMR1-interacting protein 1 (CYFIP1), which binds the fragile-X mental retardation protein, FMR1, a translational repressor
  • MKNK1, MKNK2, can modulate oncogenic translation by regulating EIF4E-EIF4E3 levels and activity in diffuse large B-cell lymphoma (DLBCL)
  • MKNK1, MKNK2 increased the binding of EIF4E to the cytoplasmic FMR1-interacting protein 1 (CYFIP1), which binds the fragile-X mental retardation protein, FMR1, a translational repressor
  • cell & other
    REGULATION
    Other phosphorylated and activated by ERK1, ERK2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS