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FLASH GENE
Symbol MTBP contributors: shn - updated : 21-03-2012
HGNC name Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
HGNC id 7417
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Mtbp, Mus musculus
ortholog to MTBP, Pan troglodytes
Homologene
FAMILY
CATEGORY regulatory , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,chromatin/chromosome,kinetochore
text localized at the kinetochores during prometaphase (
basic FUNCTION
  • putative growth regulator and tumor suppressor gene
  • promoting MDM2-mediated ubiquitination and degradation of TP53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner
  • differentially regulating the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and TP53) and in doing so significantly contributes to MDM2-dependent TP53 homeostasis in unstressed cells
  • a crucial role in proper mitotic progression and faithful chromosome segregation (
  • implicated in cancer progression
  • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text tumor cell proliferation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MDM2 (
  • suppresses cell migration, at least partially, by inhibiting ACTN4 function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • a potential biomarker for cancer progression
  • Therapy target
    ANIMAL & CELL MODELS
  • MTBP downmodulation leads to an abbreviated metaphase and insufficient mitotic arrest, abnormal chromosome segregation, aneuploidy, decreased cell proliferation, senescence, and cell death (