Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ATF7 contributors: mct - updated : 31-05-2016
HGNC name activating transcription factor 7
HGNC id 792
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a consensus sumoylation motif (IKEE), located within the N-terminal activation domain
  • a C2H2-type zinc finger domain
  • a conserved basic leucine zipper (bZIP) domain
    • conjugated PhosphoP , sumoylated , Other
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Atf7 (96.4 pc)
    homolog to murine Atf7 (97.3 pc)
    intraspecies homolog to ATF4
    homolog to ATF2
    Homologene
    FAMILY
  • BZIP family
  • cyclic AMP responsive binding protein (CREB)/activating transcription factor (ATF) family of transcription factors
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,euchromosome
    basic FUNCTION
  • transcriptional activation
  • may have a critical role in gene expression induced by social isolation stress
  • ATF7 and DMRT2 play key roles in paternal stress-induced telomere shortening in the offspring
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with other ATF
  • heterodimerize with JUN or FOS proteins and its transcriptional activity is mediated by interaction with TAF12, a subunit of the general transcription factor TFIID
    • INTERACTION
    DNA binding to cAMP responsive element
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • with PRL1 protein tyrosine phosphatase
  • binds to CRE elements within specific promoters
  • TAF12, a component of the TFIID general transcription factor, mediates ATF7 transcriptional activity through direct interactions between the two proteins
  • ATF7 silences the transcription of HTR5B by directly binding to its 5prime-regulatory region, and mediates histone H3-K9 trimethylation via interaction with the ESET histone methyltransferase
  • ATF7 interacts with TAF12 and contributes to the hypersensitivity of Osteoclast (OCL) precursors to 1,25-(OH)&
    • 8322;D&
    8323; in in Paget disease
    cell & other
    REGULATION
    activated by stress and growth factors that activate ATF2 and ATF7 mainly via sequential phosphorylation of two conserved threonine residues in their activation domain
    induced by the adenovirus E1a13S mRNA product
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei