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FLASH GENE
Symbol IL36RN contributors: mct - updated : 26 -08 -20
HGNC name interleukin 36 receptor antagonist
HGNC id 15561
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus     Homo sapiens
Respiratoryrespiratory tracttrachea    Homo sapiens
Skin/Tegumentskin   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Lymphoid    
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Digestiveepithelial cell Homo sapiens
Lymphoid/Immunemacrophage
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve stranded beta-trefoil structure
  • has the same beta-trefoil fold as other IL1 family members, and the hydrophobic core is well conserved, but there are substantial differences in the loop conformations
  • conjugated GlycoP , Other
    HOMOLOGY
    interspecies ortholog to murine Il1f5
    Homologene
    FAMILY interleukin 1 cytokine family
    CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • putative antagonist of IL1 receptor
  • involved in innate immune responses to infection and injury
  • mediates anti-inflammatory effects through its ability to induce IL4 production and this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8
  • primary inflammatory cytokine, that may play an important role in the susceptibility to developing rheumatoid arthritis
  • IL1 family receptor antagonist, which opposes the activity of the IL36A and IL36G innate cytokines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating NF-kappa B through the IL1 receptor
  • bind to specific receptors and cause activation of NFkappaB and MAP kinase
  • cell & other
    REGULATION
    induced by phorbol ester (PHA) and lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    corresponding disease(s) GPP
    Susceptibility
  • .to common forms of psoriasis
  • Variant & Polymorphism other putative dysregulation of the interleukin-36–interleukin-36Ra signaling pathway may confer a predisposition to common forms of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS