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FLASH GENE

Symbol

IL36G

contributors: mct - updated : 24-11-2017

HGNC name	interleukin 36 gamma
HGNC id	15741

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol digestive esophagus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

interleukin 1 cytokine family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	initiation and promotion of the host response to injury or infecion by activating a set of factors including NFKB, AP1 which, in turn, induce production of effectors of the immune response mediated by IL1 receptor beta
	IL36G, besides IFNG may contribute to functions of TBX21 transcription factor in immunopathology
	counting on CAMP induction in innate stimuli, such as in infection and wounding, IL36G induction by cathelicidin would explain the mechanism of initiation of skin inflammation and occasional exacerbations of psoriasis and skin diseases by general infection
	role of IL36G in promoting antitumor immune responses and suggests its potential clinical translation into cancer immunotherapy
	induction and regulation of the proinflammatory cytokine IL36G during tuberculosis
	is involved in host defense and contributes to proinflammatory responses and development of inflammatory disease

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule		inhibited by IL1 family members IL1F5, IL-1delta, interferon gamma
	stimulated fy TNFA, IL1-beta in keratinocytes

protein	stimulated the expression of the neutrophil chemokines IL8 and CXCL3 and the Th17 chemokine CCL20 in lung fibroblasts
	IL36A, IL36B, IL36G cytokines actively propagate skin inflammation via the activation of keratinocytes, APC, and, indirectly, T cells
	IL36G expression was induced by the combination of IL1B and TNF via activation of MAPKs and transcription factors, NFKB1 and JUN in colonic myofibroblasts
	directly IL36G stimulates proliferation of keratinocytes, and it induces expression of keratinocyte mitogens in fibroblasts, suggesting that the NFE2L2-IL36G axis promotes keratinocyte proliferation through a double paracrine loop

cell & other

also induced by a contact hyperimmunity reaction or herpes simplex virus

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   is strongly expressed in the aganglionic and ganglionic colon of patients with Hirschsprung disease (HSCR)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	is a valuable biomarker in psoriasis patients, both for diagnostic purposes and measurement of disease activity during the clinical course
Therapy target
	System Type Disorder Pubmed dermatology skin   might provide a future drug target, because of its potential amplifier role in TNF- and IL17 pathways in psoriatic skin inflammation

ANIMAL & CELL MODELS