motifs/domains
| a N terminal extracellular discoidin domains, similar to the dictyostelium discoideum lectin discoid 1 and the milk fat globule membrane protein of mouse, and a domain unique to the DDRs (stalk region) |
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an hydrophilic proline/glycine rich region |
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interrupted by a predicted transmembrane segment (TM) |
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an F5/8 type C domain |
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a transmembrane region followed by a large cytoplasmic juxtamembrane domain |
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14 tyrosine residues: four located in the extracellular juxtamembrane region, and the rest located in the kinase domain of the receptor |
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a C terminal kinase domain |
basic FUNCTION
| acting as a tyrosine kinase receptor for fibrillar collagen mediating fibroblast migration and proliferation |
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contributing to cutaneous wound healing |
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plays an important role in bone growth, and interaction of DDR2 with collagen is essential for proper skeletal growth |
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a critical role for type I collagen-dependent DDR2 signaling in the regulation of EMT |
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required for normal fibroblast spreading and migration independent of adhesion ligand and collagen activation of DDR2 tyrosine kinase |
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participates in hypoxia-induced breast cancer metastasis through the regulation of cell migration, invasion, and EMT |
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is a receptor tyrosine kinase that promotes the differentiation of bone-depositing cells, osteoblasts, and bone formation |
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DDR2 functions as an inhibitor of osteoclastogenesis, as well as a promoter of osteoblastogenesis |
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is critical for skeletal development and differentiation of marrow progenitor cells to osteoblasts while suppressing marrow adipogenesis |
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important for maintenance of osteoblast activity and suppression of marrow adipogenesis |
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DDR2 is likely a microenvironment sensor that regulates fibroblast migration in a collagen-rich environment |
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is a collagen-binding receptor tyrosine kinase that initiates delayed and sustained tyrosine phosphorylation signalling |
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DDR2 localisation is independent of integrin activation and the key DDR2 signalling effector SHC1 |
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collagen-responsive receptor tyrosine kinase that regulates connective-tissue formation |
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is an important regulator of bone growth and resorption, both as a promoter of osteoblastogenesis and as an inhibitor of osteoclastogenesis |
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activated DDR2 has likely a role in the migration or function of melanocytes |
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DDR1 and DDR2 are receptor tyrosine kinases that signal in response to collagen |
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oligomeric form of DDR2 extracellular domain (ECD) displayed enhanced binding to collagen and inhibition of fibrillogenesis |