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FLASH GENE
Symbol NRBP1 contributors: mct - updated : 03-09-2007
HGNC name nuclear receptor binding protein 1
HGNC id 7993
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveesophagus   highly
Endocrinepancreas   highly
 thyroid   moderately
Reproductivefemale systemuterus  moderately
 male systemtestis  highly
Urinarybladder   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines in tumor cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal PEST sequence
  • a putative binding domain for SH2 domain containing proteins
  • a protein kinase domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nrbp1 (98.32 pc)
    homolog to chicken NRBP1 (88.72 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text Co-localizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia
    basic FUNCTION
  • adaptor protein potentially linking signaling pathways involving nuclear receptors
  • may play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases
  • negatively regulating AP1 activity when associated with COPS5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MLF1
  • interacting with RAC3
  • COPS5 (NRBP1 inhibits COPS5-induced phosphorylation of c-Jun and AP-1 activation)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS