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FLASH GENE
Symbol UBAC1 contributors: mct - updated : 16-06-2021
HGNC name UBA domain containing 1
HGNC id 30221
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight CK2 phosphorylation sites
  • one helix-loop-helix (HLH) motif
  • a SRC homology (SH3) binding domain at the C terminus, P-X-X-P
  • HOMOLOGY
    Homologene
    FAMILY
  • ubiquitin family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulation of endothelial cell growth
  • expression of UBAC1 significantly impairs induction of TLR3 downstream target genes, acting on both NFKB1 and IRF3 signaling
  • UBAC1 affects viability and proliferation in primary keratinocytes
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component non-catalytic subunit of the E3 ubiquitin-protein ligase KPC complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AIRE interacts with multiple components of the transcription complex including a novel interaction with the UBA domain protein, UBAC1
  • UBAC1 regulates HOXA2 by promoting its relocation to the cytoplasm
  • PPP1CB and UBAC1 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm
  • UBAC1 participates to TLR3 signaling in keratinocytes, affecting also cell viability and proliferation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS