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FLASH GENE
Symbol PNCK contributors: npt - updated : 09-03-2006
HGNC name pregnancy up-regulated non-ubiquitously expressed CaM kinase
HGNC id 13415
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus    
Nervousbrain    
Reproductivefemale systemplacenta   
 female systemuterus   
cell lineage
cell lines
fluid/secretion
at STAGE
Text mammary development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • serine/threonine protein kinase, whose catalytic and regulatory domains are highly similar to members of the CaM kinase family
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • calcium/calmodulin dependent serine/threonine protein kinase, involved in the development of the central nervous system (hippocampus and dentrite gyrus)
  • may play a role in mammary development, and its expression may be restricted to a mammary epithelial cell type that is transformed in a subset of breast cancers
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of human primary breast cancers compared with benign mammary tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may represent an attractive therapeutic target in EGFR-regulated oncogenesis
    ANIMAL & CELL MODELS