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FLASH GENE
Symbol SLCO2B1 contributors: shn - updated : 05-09-2010
HGNC name solute carrier organic anion transporter family, member 2B1
HGNC id 10962
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
Cardiovascularheart   lowly
Digestiveliver   highly
Endocrinepancreas   lowly
Nervousbrain   lowly
Reproductivefemale systemovary  lowly
 male systemtestis  lowly
Respiratorylung   lowly
Urinarykidney   lowly
Visualeyeretina  lowly
 eyeanterior segmentiris lowly
 eyeanterior segmentcornea lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningretinal pigment epithelium (RPE) highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight transmembrane domains
  • N-glycosylation sites
  • HOMOLOGY
    interspecies ortholog to Slco2b1, Rattus norvegicus
    ortholog to slco2b1, Danio rerio
    ortholog to SLCO2B1, Pan troglodytes
    ortholog to Slco2b1, Mus musculus
    Homologene
    FAMILY organic anion transporting polypeptide (OATP) family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • transport of 3(H) estrone-3-sulfate
  • a physiological role in the placental uptake of fetal-derived sulfated steroids (St-Pierre et al, 2002)
  • involved in de novo synthesis of placental estrogens but may contribute to the clearance of estrogen sulfates from foetal circulation (Ugele et al, 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text organic anion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS