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FLASH GENE
Symbol ZNF281 contributors: mct - updated : 14-11-2017
HGNC name zinc finger protein 281
HGNC id 13075
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta,highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four Krüppel type zinc finger motifs
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating ornithine decarboxylase gene expression
  • regulating gastrin gene expression
  • involved in transcriptional regulation
  • mediates NANOG autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
  • epithelial-mesenchymal transition (EMT)-inducing transcription factor (EMT-TF)
  • zinc-finger factor involved in the control of cellular stemness and epithelial-mesenchymal transition (EMT)
  • is a key transcriptional regulator for primed pluripotency that also functions as a barrier toward achieving naive pluripotency in ESCs
  • involved in embryonic stem cell differentiation and tissue development
  • role of ZNF281 in pancreatic cancer progression
  • acts at a nexus of cardiac and inflammatory gene programs, which exert opposing influences on fibroblast to cardiac reprogramming
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the GC rich promoter element of gastrin and ODC
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • directly activate NANOG expression by binding to a site in the promoter in very close proximity to the POU5F1 and SOX2 binding sites
  • is required for NANOG binding to its own promoter, suggesting that NANOG-associated repressive complex(es) involving ZNF281 may fine-tune NANOG expression for pluripotency of ESCs
  • ZNF281 plays an important role in the maintenance and osteogenic differentiation of stem cells via the transcriptional regulation of genes including CTNNB1
  • NANOG is subjected to a negative autoregulatory mechanism, i.e., autorepression, in ESCs, and such autorepression requires the coordinated action of the NANOG partner and transcriptional repressor ZNF281
  • as ZNF281 physically interacts with the transcription factors NANOG, OCT4, SOX2, and MYC, it has been implicated in the regulation of pluripotency, stemness, and cancer
  • involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
  • ZFP281 interacts with TET1, but not TET2
  • ZFP281 is a critical factor generally associating with AFF3 at enhancers and functioning together with AFF3 in regulating the expression of a subset of genes
  • promotes pancreatic cancer cells proliferation and invasion by interacting and up-regulating CTNNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS