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FLASH GENE
Symbol ADAM29 contributors: mct - updated : 10-04-2012
HGNC name ADAM metallopeptidase domain 29
HGNC id 207
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific
cell lineage spermatogenic cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • a Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine rich domain
  • an EGF-like repeat
  • a transmembrane domain and a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a disintegrin and metalloprotease (likely non catalytic), cell surface adhesion protein involved in spermatogenesis
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    often mutated in melanoma, and could play a role in melanoma progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia
  • Therapy target
    ANIMAL & CELL MODELS