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FLASH GENE
Symbol MYBBP1A contributors: mct - updated : 24-01-2015
HGNC name MYB binding protein (P160) 1a
HGNC id 7546
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrinepancreas    
Lymphoid/Immunespleen   highly
Nervousbrain    
Reproductivefemale systemuteruscervix moderately
 male systemprostate   
Respiratoryrespiratory tractlarynx  moderately
Skin/Tegumentskin   moderately
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Mybbp1a (69.9 pc)
homolog to murine Mybbp1a (71.3 pc)
Homologene
FAMILY
CATEGORY regulatory , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
text
  • predominantly nucleolar
  • shuttling between the nucleus and cytoplasm
  • nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1
  • when rRNA transcription was suppressed by nucleolar stress, MYBBP1A translocated to the nucleoplasm and facilitated TP53-EP300 interaction to enhance TP53 acetylation
  • nucleolar stress induces translocation of the nucleolar protein MYBBP1A from the nucleolus to the nucleoplasm and enhances TP53 activity
  • basic FUNCTION
  • may activate or repress transcription via interactions with sequence specific DNA-binding proteins
  • repressing JUN, MYB and PPARGC1A
  • stimulating transcription by AHR
  • may function to regulate cell type specific genes
  • may connect the ribosome biogenesis and the Myb-dependent transcription, which controls cell cycle progression and proliferation
  • novel substrate of AURKB and may be involved in mitosis (Perrera 2010)
  • regulates levels and processing of pre-ribosomal RNA (
  • co-repressor role of MYBBP1A in rRNA expression
  • is an essential gene with novel roles at the pre-mitotic level and potential tumor suppressor activity
  • plays catalytic roles in TP53 acetylation and activation
  • nucleolar stress induces translocation of the nucleolar protein MYBBP1A from the nucleolus to the nucleoplasm and enhances TP53 activity
  • likely plays a pivotal role in the cellular stress response
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to JUN and MYB via the leucine zipper regions present in these proteins
  • binding to PPARGC1A
  • binding to AHR
  • binding to KPNA2
  • is a novel substrate of VHL
  • associated with both the RNA polymerase I complex and the ribosome biogenesis machinery
  • specifically interacts with nonacetylated TP53 and induces TP53 acetylation
  • MYBBP1A binds to SIRT7 and is a novel negative regulator of SIRT7
  • functions to enhance TP53 tetramerization that is necessary for TP53 activation
  • ANKH /MYBBP1A and SPHK1 interactions stimulate catabolic events in IL1B-mediated cartilage degradation
  • interaction of MYBBP1A with CDK2 and TPP2, to form a protein-protein interaction network
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS