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FLASH GENE
Symbol SLC7A6 contributors: mct - updated : 27-06-2011
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
HGNC id 11064
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Endocrinepancreas     Homo sapiens
Reproductivefemale systemovary   
Urinarykidneynephronrenal capsuleglomerulushighly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
Urinarypodocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text
  • spleen
  • in the fetal kidney, we observed intense expression at the capillary loops stage of renal development
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments
  • cytoplasmic N and C termini
  • two conserved cysteine residues between TM3 and TM4
  • the first residue interacting with a cysteine in the 4F2 heavy chain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 7, cationic amino-acid
  • k1 glycoprotein associated aminoacid transporter family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • high-affinity permease for methionine
  • potentially a major contribution to the transport of cationic amino acids in pachytene spermatocytes and early spermatids
  • Na+-independent neutral l-amino acid transporter, that may may play a crucial role in the development and maintenance of podocyte structure and function by regulating protein synthesis and the actin cytoskeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    PATHWAY
    metabolism aminoacid
    signaling
    a component
  • heterodimerizing with the cell surface glycoprotein to form a complex mediating y+L -type transporter exchanging cationic aminoacids and/or neutral aminoacids together with sodium
  • system-L (SLC7A5, SLC7A8, SLC7A7, SLC7A6), which is the major transporter of tyrosine
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SLC7A7
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS