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FLASH GENE
Symbol DDX17 contributors: mct - updated : 01-02-2018
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
HGNC id 2740
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuterus  highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N-terminal RGG box repeats
  • a central conserved DEAD box domain
  • a run of 7 glycines
  • a serine/glycine-rich C-terminal domain ending in 9 consecutive prolines
  • HOMOLOGY
    interspecies ortholog to rattus Ddx17 predicted
    ortholog to murine Ddx17
    Homologene
    FAMILY
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 family
  • DEAD box helicase family
  • DDX5/DDX17 subfamily
  • CATEGORY enzyme , regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly
  • acting as an RNA helicase
  • may be an alternative splicing regulatory factor
  • is required for optimal function of the zinc-finger antiviral protein.
  • DDX5 and DDX17 have been shown to act as transcriptional
  • co-activators for a diverse range of transcription factors, including oestrogen receptor-alpha (ESR1)
  • crucial role for DDX17 in ESR1 co-activation and oestrogen-dependent cell growth and likely distinct but important roles for both DDX5 and DDX17 in regulating ESR1 activity in breast cancer
  • critical role for DDX5 and DDX17 in tumor cell migration through the fine regulation of NFAT5 pathway
  • DDX5 and DDX17 are members of a large family of highly conserved proteins that are involved in gene-expression regulation
  • RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation
  • has dual roles in the recognition of stem loops: in the nucleus for endogenous microRNA (miRNA) biogenesis and in the cytoplasm for surveillance against structured non-self-elements
  • DDX17 is a SOX2-binding protein in ER-positive breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • ATP
  • protein
  • DDX5 and DDX17 have a dual role in the control of the pro-migratory NFAT5 transcription factor
  • DDX5 and DDX17 act are transcriptional coactivators of NFAT5 and are required for activating NFAT5 target genes involved in tumor cell migration
  • binding between DDX17 and SOX2, although this interaction was largely restricted to reporter responsive (RR) cells
  • DDX17 and KHSRP influence AGO2 stability by regulating miRNA levels in the cell and that loss of DDX17/KHSRP results in a decrease of unloaded AGO2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    DDX17 inhibition may be a promising strategy to overcome acquired resistance of gefitinib in NSCLC patients
    ANIMAL & CELL MODELS