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FLASH GENE
Symbol AKT3 contributors: mct - updated : 29-11-2014
HGNC name v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
HGNC id 393
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver   lowly
Nervousbrain   highly
Reproductivemale systemtestis  lowly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in heart, liver, brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SH2 and a pleckstrin (PH) homology N terminal domain
  • a short alpha helical linker
  • a C terminal kinase domain
  • HOMOLOGY
    interspecies homolog to V-akt murine thymoma viral oncogene 3
    homolog to C.elegans F28H6.1
    Homologene
    FAMILY
  • Ser/Thr protein kinase, B family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • localized in both the nucleus and nuclear membrane
  • basic FUNCTION
  • AKT is a key regulator for cell growth, cell survival and metabolic insulin action
  • involved in the regulation of diverse cellular functions such as cell proliferation, energy metabolism, and apoptosis
  • AKT2 and AKT3 play an important role in the viability of human malignant glioma cells
  • may oppose AKT1 in lung tumorigenesis and lung tumor progression
  • AKT1 and AKT3 are essential for the proliferation of reprogrammed cells
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text survival of lymphoid and other cell types
    PATHWAY
    metabolism
    signaling
  • central role of PI3K/AKT signaling in vascular, limb and brain development
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhanced AKT2 or AKT3 activation also promotes reprogramming and coordinates with LIF to activate STAT3
  • AKT3 is likely a regulator of mitochondrial dynamics in the vasculature via regulation of XPO1-dependent nuclear export
  • cell & other
    REGULATION
    activated by growth factors via PI3K (phosphatidyl inositol 3-kinase) binding to PH domain in the antiapoptotic PI3K pathway induced by insulin growth factor 1, and maybe other
    coactivated by TCL1
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL1Q44 , MPPH2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in estrogen receptor-negative breast tumor
    tumoral       gain of function
    associated with the survival of melanoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene for microcephaly and corpus callosum agenesis in 1qter microdeletion syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    targeting AKT2 and AKT3 may hold promise for the treatment of patients with gliomas (PMID: 20167810)
    ANIMAL & CELL MODELS