Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STK25 contributors: mct - updated : 27-03-2018
HGNC name serine/threonine kinase 25 (STE20 homolog, yeast)
HGNC id 11404
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestine  highly
 stomach   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
kinase domain in N terminus
HOMOLOGY
interspecies homolog to C.elegans f14h12.4
Homologene
FAMILY
  • serine/threonine kinase family, GCK III subfamily
  • Ste20 superfamily of kinases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • functioning in a signaling pathway required for cell migration and polarization
  • play distinctly different roles in stressed versus non-stressed cells, regulating cell death in the former
  • can induce cell death entering the nucleus, but this is not necessarily the only way it can kill a cell
  • RELN and STK25 have opposing roles in neuronal polarization and dendritic Golgi deployment
  • STK25 regulates lipid partitioning in human liver cells by controlling triacylglycerol (TAG) synthesis as well as lipolytic activity
  • is a critical regulator of ectopic lipid deposition, systemic glucose, and insulin homeostasis
  • multiple roles of STK25 in nonalcoholic steatohepatitis (NASH) pathogenesis
  • is a critical regulator of liver steatosis, hepatic lipid metabolism and whole body glucose and insulin homeostasis
  • STK25 emerges as a new regulator of the complex interplay between lipid storage, mitochondrial energetics and insulin action in skeletal muscle
  • is a critical regulator of ectopic fat storage, meta-inflammation, and fibrosis in liver and skeletal muscle
  • is a critical regulator of energy homeostasis and Nonalcoholic fatty liver disease (NAFLD) progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PDCD10 can heterodimerize with GCKIII kinases (STK24, MST4, and STK25) to regulate cardiovascular development
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activated by the Golgi matrix protein GOLGA2 and plays a role in cell migration through its substrate YWHAZ
  • STK25 regulates neuronal polarization and Golgi morphology in an antagonistic manner to DAB1
  • PDCD10 interacts with STK25, an oxidant stress response kinase related to sterile-20 (Ste20) that is activated by oxidative stress and induces apoptotic cell death
  • CCM2 can be phosphorylated by STK25, and the kinase activity of STK25 is required for death signaling
  • STK26 and STK25 belong to the Ste20-like kinases and interact with PDCD10 which is closely linked to cancer diseases
  • STK25 as the kinase component of STRIPAK can inhibit the function of the STRIPAK inhibitor SAV1
  • cell & other
    REGULATION
    activated by oxidant stress and by autophosphorylation
    not activated by growth factors,alkylating agents,cytokines or environmental stress
    chemical anoxia in a caspase-independent manner, something that has not been described for any other of the GCKIII family members
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q37
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in conditions of excess dietary fuels associates with a shift in the metabolic balance in peripheral tissues from lipid oxidation to storage, leading to a systemic insulin resistance
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene pseudopseudohypoparathyroidism (PPHP)
    for brachymetaphalangism and/or obesity in the del2q37 syndrome
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    reducing STK25 function may provide a new strategy for the treatment of patients with type 2 diabetes
    digestiveliver 
    reducing STK25 function may provide a new strategy for the treatment of patients with Nonalcoholic fatty liver disease (NAFLD)
    metabolism  
    potential drug target for metabolic disease
    ANIMAL & CELL MODELS
  • Stk25-/- mice are protected against methionine and choline-deficient (MCD) diet-induced NASH, as evidenced by repressed liver steatosis, oxidative damage, inflammation, and fibrosis, whereas Stk25 transgenic mice developed a more severe nonalcoholic steatohepatitis (NASH) phenotype, compared with corresponding wild-type littermates
  • transgenic mice overexpressing STK25, when challenged with a high-fat diet, develop reduced glucose tolerance and insulin sensitivity compared to wild-type siblings